Strawberries Activate Proteins That Prevent Diabetes and Heart Disease

Game, set and match to strawberries. Strawberries, the traditional summer treat associated with Wimbledon could be serving up some unexpected health benefits. Scientists at the University of Warwick have been studying the beneficial effects of strawberries on our cardiovascular health, particularly around how they prevent the development of heart disease and diabetes. Professor Paul Thornalley from Warwick Medical School heads the team that discovered extracts from strawberries positively activate a protein in our bodies called ‘Nrf2’ which is shown to increase antioxidant and other protective activities. This protein works to decrease blood lipids and cholesterol, the very things which can lead to cardiovascular problems. Eating strawberries has previously been found to counter post-meal blood

glucose and low density lipoprotein, or ‘bad’ cholesterol and therefore decrease risk of diabetes and heart disease, but this is the first time that strawberry extracts have been proved to actively stimulate proteins that offer us protection against disease. Professor Thornalley explained: We’ve discovered the science behind how strawberries work to increase our in-built defences to keep cells, organs and blood vessels healthy and which can reduce the risk of developing cardiovascular problems such as heart disease and diabetes. So don’t feel guilty about serving up strawberries and cream … although I’d suggest more strawberries and less or even no cream! Screening and mathematical modelling techniques developed at the University of Warwick can now take this research further to help identify the best varieties of strawberries, how they are served or processed and how many strawberries should be eaten for optimum health benefit. The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and is led by Professor Paul Thornalley with Dr Naila Rabbani (Medical School), Dr Guy Barker (Life Sciences) and Professor David Rand (Systems Biology). Professor Thornalley will be presenting the research at the forthcoming 16th biennial meeting for the Society for Free Radical Research International (SFRRI) at Imperial College London.  – Professor Paul Thornalley: Professor of Systems Biology and Deputy Head,

Division of Metabolic and Vascular Health. Research profile: Leading a multi-disciplinary team working in the field of disease mechanisms – particularly the study of damage to the proteome by glycation, oxidation and nitration, related enzymatic countermeasures raised by transcription factor Nrf2 and antioxidant response element (ARE)-regulated expression and other metabolic dysfunction. A distinctive and pioneering expertise is glycation by the dicarbonyl metabolite methylglyoxal and prevention of this by the glyoxalase system. Diseases under current investigation are: vascular complications of diabetes, cardiovascular disease, renal failure, ageing and glyoxalase 1-linked multidrug resistant tumours. Novel therapeutics development under current investigation are: high dose thiamine therapy for the prevention of diabetic complications and Nrf2 activators for healthy ageing. I have a particular interest in: (i) inducers of glyoxalase 1 for diabetic vascular disease and healthy ageing (synthetic drug discovery and development, and glyoxalase 1 inducer novel functional foods), and (ii) glyoxalase 1 inhibitors for glyoxalase 1-mediated multidrug resistant tumours (synthetic drug discovery and development). Novel diagnostics under investigation are: biomarkers for vascular and metabolic health, skeletomuscular joint health, and healthy ageing. News from: Warwick Medical School

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