New Hope from a Chinese Club Moss and Alzheimer’s Disease

Scientists Create Natural Alzheimer’s-Fighting Compound in Lab. New Haven, Conn. — Scientists at Yale University have developed the first practical method to create a compound called huperzine A in the lab. The compound, which occurs naturally in a species of moss found in China, is an enzyme inhibitor that has been used to treat Alzheimer’s disease in China since the late 1990s and is sold in the U.S. as a dietary supplement to help maintain memory. Scientists believe it could also potentially combat the effects of chemical warfare agents.Until now, researchers have only been able to derive small amounts of the compound directly from the Huperzia serrata plant, or had to resort to lengthy and cumbersome methods to synthesize it in the lab.Now researchers at Yale have developed a practical and cost-effective method to synthesize huperzine A in the lab. The process requires just eight steps and produces a yield of 40 percent. Previously, the best synthetic techniques had required twice as many steps and achieved yields of only two percent. “Being able to synthesize large amounts of huperzine A in the lab is crucial because the plant itself, which has been used in Chinese folk medicine for centuries, takes decades to grow and is nearing extinction due to overharvesting,” said Seth Herzon, the Yale chemist who led the research, which is described in the Aug. 25 issue of the journal Chemical Science. In some places, huperzine A can cost up to $1,000 per milligram. Herzon and his team produced several grams of the compound in their lab and are capable of creating much more. They

believe they will be able to drive the cost down to just 50 cents per milligram (a projected typical dose is about one milligram per day), and have partnered with an industrial firm to help produce it on larger scales.The firm plans to comprehensively evaluate the therapeutic potential of huperzine A by conducting clinical trials for several different neurological disorders in the U.S. In addition, the Herzon lab and the firm are working with the U.S. Army, which is interested in huperzine A’s potential in blocking the effects of chemical warfare agents, he said. The compound has been shown to protect primates against chemical warfare agents, without side effects.Other Alzheimer’s treatments based on enzyme inhibitors are currently prescribed in the U.S., but huperzine A binds better, is more easily absorbed by the body and last longer in the body than other treatments, Herzon said. “We believe huperzine A has the potential to treat a range of neurologic disorders more effectively than the current options available,” Herzon said. “And we now have a route to huperzine A that rivals nature’s pathway.”Other authors of the paper include Maung Kyaw Moe Tun and Daniel-Joachim Wüstmann, both of Yale. –  Prof  Seth Herzon   assistant Professor of Chemistry Member of Yale faculty.  Research in the Herzon group encompasses the disciplines of natural products

synthesis and synthetic methods development. In the former area, we are working to develop efficient, flexible syntheses of complex natural products. Our synthetic routes will present challenges to the capabilities of the field and, in the search for solutions, force an extension of its current boundaries. A prudent, thoughtful approach to target selection is undertaken so that the success of these investigations may potentially serve a broader cause as well. For example, our efforts may provide synthetic material for the study and treatment of human diseases, or alternatively, facilitate investigation of the structure and function of otherwise inaccessible molecules. Thus, the syntheses we develop may be incorporated into larger interdisciplinary programs, however a passion for complex molecule synthesis is what drives us and this forms the core of our program.In the area of synthetic methods, we seek to identify and reduce to practice essential transformations that are currently not feasible, or only of limited scope. In searching for solutions to these problems we will make use of any tools available to us. Thus, our investigations might lead us to explore the chemistry of novel organic and inorganic reagents, and organometallic complexes, and will be complemented by mechanistic studies, where appropriate. The primary goal of these investigations is the development of practical synthetic methods of broad utility. News from: Yale University

Dear friend,this is an open project and accepts the help of anyone willing to make positive thinking. Send your proposals (articles, cartoons, funny pictures and videos)

Editorial Staff Tel. +39 0574 442669
Promotion & Advertising Tel. +39 0574 1746090

Support and Spread the only e-magazine dedicated to good news and smiles!

Write to: goodnewsenglish@goodnews.ws

Show on your site a link to our www.goodnews.ws

GOODNEWS Cerca il Meglio per te

^ SHOPPING ^

Good News, good, news, network, positive, uplifting, l’agenzia di buone notizie e ufficio comunicati stampa online di informazione alternativa e positiva, di salute naturale ecoturismo bioedilizia, agricoltura biologica, alimentazione naturale, energie alternative fantascienza, misteri, parapsicologia, lavoro etico, autoaiuto, selfhelp, webreader, sapere.it.

Share This Post