According to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM), eating a meal quickly, as compared to slowly, curtails the release of hormones in the gut that induce feelings of being full. The decreased release of these hormones, can often lead to overeating. “Most of us have heard that eating fast can lead to food overconsumption and obesity, and in fact some observational studies have supported this notion,” said Alexander Kokkinos, MD, PhD, of Laiko General Hospital in Athens Greece and lead author of the study. “Our study provides a possible explanation for the relationship between speed eating and overeating by showing that the rate at which someone eats may impact the release of gut hormones that signal the brain to stop eating.” In the last few years, research regarding gut hormones, such as peptide YY (PYY) and glucagon-like peptide (GLP-1), has shown that their release after a meal acts on the brain and induces satiety and meal termination. Until now, concentrations of appetite-regulating hormones have not been examined in the context of different rates of eating. In this study, subjects consumed the same test meal, 300ml of ice-cream, at different rates. Researchers took blood samples for the measurement of glucose, insulin, plasma lipids and gut hormones before the meal and at 30 minute intervals after the beginning of eating, until the end of the session, 210 minutes later. Researchers found that subjects who took the full 30 minutes to finish the ice cream had higher concentrations of PYY and GLP-1 and also tended to have a higher fullness rating.
“Our findings give some insight into an aspect of modern-day food overconsumption, namely the fact that many people, pressed by demanding working and living conditions, eat faster and in greater amounts than in the past,” said Kokkinos. “The warning we were given as children that ‘wolfing down your food will make you fat,’ may in fact have a physiological explanation.” Other researchers working on the study include Kleopatra Alexiadou, Nicholas Tentolouris, Despoina Kyriaki, Despoina Perrea and Nicholas Katsilambros of Athens University Medical School in Greece; and Carel le Roux, Royce Vincent, Mohammad Ghatei and Stephen Bloom of Imperial College in London, United Kingdom. The article, “Eating slowly increases the postprandial response of the anorexigenic gut hormone, Peptide YY and Glucagon like peptide-1,” will appear in the January 2010 issue of JCEM.Founded in 1916, The Endocrine Society is the world’s oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society’s membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied, and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland.news from scienceblog.com/ – Eating Slowly Increases the Postprandial Response of the Anorexigenic Gut Hormones, Peptide YY and Glucagon-Like Peptide-1. Context:
The rate at which people eat has been suggested to be positively associated with obesity, although appetite and related gut hormones have not been measured. Objective: The objective of the study was to determine whether eating the same meal at varying speeds elicits different postprandial gut peptide responses. Design and Setting: This was a crossover study at a clinical research facility. Study Participants: Seventeen healthy adult male volunteers participated in the study. Intervention: A test meal consisting of 300 ml ice cream (675 kcal) was consumed in random order on two different sessions by each subject: meal duration took either 5 or 30 min. Main Outcome Measures: The postprandial response of the orexigenic hormone ghrelin and the anorexigenic peptides peptide YY and glucagon-like peptide-1 over 210 min was assessed. Visual analog scales for the subjective feelings of hunger and fullness were completed throughout each session. Results: Peptide YY area under the curve (AUC) was higher after the 30-min meal than after the 5-min meal (mean ± SEM AUC 5 min meal: 4133 ± 324, AUC 30 min meal: 5250 ± 330 pmol/liter · min, P = 0.004), as was glucagon-like peptide-1 AUC (mean ± SEM AUC 5 min meal: 6219 ± 256, AUC 30 min meal: 8794 ± 656 pmol/liter · min, P = 0.001). There was a trend for higher visual analog scale fullness ratings immediately after the end of the 30-min meal compared with immediately after the 5-min meal. There were no differences in ghrelin response. Conclusions: Eating at a physiologically moderate pace leads to a more pronounced anorexigenic gut peptide response than eating very fast. Alexander Kokkinos*, Carel W. le Roux, Kleopatra Alexiadou, Nicholas Tentolouris, Royce P. Vincent, Despoina Kyriaki, Despoina Perrea, Mohammad A. Ghatei, Stephen R. Bloom, and Nicholas Katsilambros. First Department of Propaedeutic Medicine (A.K., K.A., N.T., D.K., D.P., N.K.), Athens University Medical School, Laiko General Hospital, 11527 Athens, Greece; and Department of Metabolic Medicine (C.W.l.R., R.P.V., M.A.G., S.R.B.), Hammersmith Hospital, Imperial College, London W12 ONN, United Kingdom. news from jcem.endojournals.org
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